N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
sodium hydroxide T=100°C; 13 h;
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
反应条件
sodium amide; xylene
参考文献
Schuler,W.A.; Klebe,H.
Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180
反应条件
hydrogenchloride; methanol; alkaline aqueous potassium borate solution Vor der Umsetzung mit <3-Chlor-propyl>-dimethyl-amin unter Stickstoff wurde das Reaktionsprodukt mit Butyllithium in Aether behandelt;
参考文献
Merck and Co. Inc.
Patent: US2951082 , 1956 ;
反应条件
1: With sodium hydride in dimethyl sulfoxide T=25°C; 2.67 h; 2: With hydrogen bromide in water T=10°C; pH=7;
参考文献
ADORKEM TECHNOLOGY SPA
Patent: WO2004/80988 A1, 2004 ;
Location in patent: Page 22 ;
反应条件
1: 1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 1-dimethylamino-3-chloropropane With sodium hydride in dimethyl sulfoxide; toluene T=20 - 25°C; 2.75 - 3.83333 h; 2: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile With hydrogen bromide in water; isopropyl alcohol; toluene pH=8 - 8.5; 13 h;
参考文献
NATCO PHARMA LTD; VENKAIAH CHOWDARY, Nannapaneni; KHADGAPATHI, Podile
Patent: WO2004/94399 A1, 2004 ;
Location in patent: Page 15-16 ;
反应条件
1: sodium hydride in paraffin oil (nujol); dimethyl sulfoxide T=60 - 65°C; Heating / reflux; 2: 1-(4'-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 1-dimethylamino-3-chloropropane With sodium methylsulfinylmethanide in water; dimethyl sulfoxide; toluene T=25 - 30°C; 2.75 - 3.83333 h; 3: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile With hydrogen bromide in water; isopropyl alcohol; toluene pH=8.5 - 9; 11 h;
参考文献
WO2004/94399 A1, ;
Page 14-15 ;
反应条件
1: 5-bromo-1-(4-fluorophenyl)phthalan With sodium hydride; dimethyl sulfoxide in paraffin oil (nujol) T=20 - 25°C; 2.25 - 3.33333 h; 2: 1-dimethylamino-3-chloropropane in dimethyl sulfoxide; toluene T=25 - 30°C; 0.5 h; 3: With methanol in dimethyl sulfoxide; toluene
参考文献
NATCO PHARMA LIMITED
Patent: WO2004/16602 A1, 2004 ;
Location in patent: Page 19-20 ;
反应条件
1: With sodium hydride in 1,3-dimethyl-imidazolidin-2-one; toluene T=40 - 50°C; 0.666667 h; 2: With hydrogenchloride; water T=65 - 70°C; 3 h; 3: With sodium hydroxide in water; toluene Product distribution / selectivity;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2006/57261 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;
反应条件
N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2002/62040 A1, 2002 ;
反应条件
N,N,N',N,-tetramethylethylenediamine in N,N-dimethyl-formamide; toluene
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2002/62040 A1, 2002 ;
