1: 79 percent / m-chloroperbenzoic acid / CH2Cl2 / 1.25 h / -78 °C 2: 53 percent / lithiumhydroxyde / tetrahydrofuran; H2O / 24 h / 50 °C View Scheme

Multi-step reaction with 3 steps 1: 83 percent / ethanol / 0.5 h / Ambient temperature2: 78 percent / TMEDA, n-butyllithium / tetrahydrofuran; hexane / from -78 to room temperature, 17 h3: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / Ambient temperature  

Multi-step reaction with 5 steps 1: 87 percent / formic acid / 18 h / Ambient temperature2: 86 percent / ozone / CH2Cl2 / -78 °C3: 83 percent / ethanol / 0.5 h / Ambient temperature4: 78 percent / TMEDA, n-butyllithium / tetrahydrofuran; hexane / from -78 to room temperature, 17 h5: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 2.5 h / Ambient temperature