2,4-二氟-n-[2-甲氧基-5-[4-(4-吡嗪)-6-喹啉]-3-吡啶]苯磺酰胺合成路线 （共 12 条）
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 3: sodium iodide / anhydrous propionitrile / 96 h / Reflux 4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux 5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / 1,4-dioxane / Reflux 6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
反应条件
1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C 4: sodium iodide / anhydrous propionitrile / 96 h / Reflux 5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / Reflux 6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / 1,4-dioxane / Reflux 7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
