3-甲氧基-5-甲基苯甲酸甲酯合成路线 （共 10 条）
反应条件
potassium carbonate in acetone Reflux;
参考文献
Karmakar, Raju; Pahari, Pallab; Mal, Dipakranjan
Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4042 - 4045
反应条件
caesium carbonate; 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=20°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/105058 A2, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/105058 A2
反应条件
1: methyl 3-hydroxy-5-methylbenzoate With sodium hydride in N,N-dimethyl-formamide 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
ASTRAZENECA AB
Patent: US2008/4302 A1, 2008 ;
Location in patent: Page/Page column 105 ;
US 20080004302 A1
反应条件
1: alkali 2: sulfuric acid View Scheme
参考文献
Journal of the Chemical Society, , vol. 99, p. 1718
参考文献
Journal of the Chemical Society, , vol. 99, p. 1718
反应条件
T=200°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 120, p. 1339 - 1346
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane HeatingIrradiation;
参考文献
Deshpande, Prashant P.; Martin, Olivier R.
Tetrahedron Letters, 1990 , vol. 31, # 44 p. 6313 - 6316
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=23°C; 12 h;
参考文献
De Frutos, Oscar; Atienza, Carmen; Echavarren, Antonio M.
European Journal of Organic Chemistry, 2001 , # 1 p. 163 - 171
反应条件
1: LiAlH4 2: 1.) BuLi, 2.) I2 / hex., Et2O, -78 deg C View Scheme
参考文献
Jung
Tetrahedron Letters, 1988 , vol. 29, # 21 p. 2517 - 2520
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran / 12 h / 23 °C
2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 2.5 h / 23 °C
View Scheme
参考文献
De Frutos, Oscar; Atienza, Carmen; Echavarren, Antonio M.
European Journal of Organic Chemistry, 2001 , # 1 p. 163 - 171
