4-(2,5-二甲氧基苯基)丁酸合成路线 （共 16 条）
反应条件
1: PPA
2: 60 percent / t-BuOK; O2 / 2-methyl-propan-2-ol / 0.75 h / 25 °C
View Scheme
参考文献
Ameer, Farouk; Giles, Robin G. F.; Green, Ivan R.; Pearce, Rene
Synthetic Communications, 2004 , vol. 34, # 7 p. 1247 - 1258
反应条件
1: 50 percent / PPA
2: 95 percent / sodium borohydride
3: 95 percent / (Vilsmeier-Haack formylation)
4: 85 percent / silver oxide
View Scheme
参考文献
Reddy, M. Parameswara; Rao, G. S. Krishna
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3549 - 3550
反应条件
1: 50 percent / PPA
2: 95 percent / sodium borohydride
3: 95 percent / (Vilsmeier-Haack formylation)
View Scheme
参考文献
Reddy, M. Parameswara; Rao, G. S. Krishna
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3549 - 3550
反应条件
1: (CF3CO)2O / trifluoroacetic acid / 0.08 h
2: 42 percent / tetrahydrofuran
View Scheme
参考文献
Reddy, M. Parameswara; Rao, G. S. Krishna
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3549 - 3550
反应条件
1: 60 percent / polyphosphoric acid / 1 h / 70 °C
2: 40 percent / NaBr, Me3SiCl, DMSO / acetonitrile / 1.5 h
View Scheme
参考文献
Yang, Zhen; Cui, Yu Xin; Wong, Henry N. C.; Wang, Ru Ji; Mak, Thomas C. W.; et al.
Tetrahedron, 1992 , vol. 48, # 16 p. 3293 - 3302
反应条件
1: 100 percent / Br2 / acetic acid / Ambient temperature
2: 86 percent / polyphosphoric acid / 0.67 h / 75 °C
3: NaBH4 / ethanol / Ambient temperature
4: p-toluenesulfonic acid / benzene / 1.5 h / Heating
View Scheme
参考文献
Braun, Manfred
Tetrahedron, 1984 , vol. 40, # 22 p. 4585 - 4592
