1,5-二甲基-3-(三氟甲基)-1H-吡唑-4-甲醛合成路线 (共 1 条)
反应条件
1: 4-bromo-3-trifluoromethyl-1,5-dimethylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.05 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; pentane T=-78 - 0°C; 2 h; 3: With hydrogenchloride; water in tetrahydrofuran; pentane T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/141020 A1, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/141020 A1