反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C to RT, 3 h
2: 77 percent / AlCl3 / CH2Cl2 / 63 h / Ambient temperature
3: LiAlH4 / tetrahydrofuran / 2 h / Heating
4: 4.31 g / pyridine, MeSO2Cl / 1 h / 0 °C
5: 89 percent / SnCl4 / CS2 / 3 h / Ambient temperature
6: 57 percent / NaH, 15-crown-5 / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
