反应条件
1.1: pyridine; titanium tetrachloride / tetrahydrofuran; tetrachloromethane / 72 h / 0 - 25 °C
2.1: tetrahydrofuran / -5 - 0 °C
3.1: potassium hydroxide / ethanol / 13 h / Reflux
3.2: Acidic conditions
4.1: ethanol / 6 h / 160 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / -5 - 25 °C
View Scheme
参考文献
Kerns, Jeffrey K.; Nie, Hong; Bondinell, William; Widdowson, Katherine L.; Yamashita, Dennis S.; Rahman, Attiq; Podolin, Patricia L.; Carpenter, Donald C.; Jin, Qi; Riflade, Benoit; Dong, Xiaoyang; Nevins, Neysa; Keller, Paul M.; Mitchell, Laura; Tomaszek, Thaddeus
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4409 - 4415