反应条件
1: 1.) butyllithium, diisopropylamine, 2.) HMPA / 1.) hexane, THF, - 78 deg C, 20 min, 2.) hexane, THF, - 78 deg C, 45 min
2: 52 percent / lithium tetrahydridoaluminate / diethyl ether / 2 h / Heating
3: 2.) Et3N / 1.) toluene, reflux, 1 h, 2.) toluene, reflux, 21 h
4: 45 percent / NaOH / H2O; methanol / 16 h / 25 - 27 °C
View Scheme
参考文献
Bicking; Bock; Cragoe Jr.; DiPardo; Gould; Holtz; Lee; Robb; Smith; Springer; Blaine
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 342 - 348
