1: 3-methyliodobenzene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=20°C;
2: cyclohexanone in tetrahydrofuran
T=20°C; P=7757.43 Torr;
3: With ammonium chloride in tetrahydrofuran; water
参考文献
Brodmann, Tobias; Koos, Peter; Metzger, Albrecht; Knochel, Paul; Ley, Steven V.
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1102 - 1113
1: 1-bromo-3-methyl-benzene With iodine; magnesium in diethyl ether
T=0 - 20°C; 0.5 h; Inert atmosphere;
2: cyclohexanone in diethyl ether
T=20°C; Inert atmosphere;
参考文献
Rono, Lydia J.; Yayla, Hatice G.; Wang, David Y.; Armstrong, Michael F.; Knowles, Robert R.
Journal of the American Chemical Society, 2013 , vol. 135, # 47 p. 17735 - 17738
1: 1-bromo-2-methyl benzene With n-butyllithium in diethyl ether
T=-78°C; Inert atmosphere;
2: cyclohexanone in diethyl ether
T=20°C; Inert atmosphere;
参考文献
Rono, Lydia J.; Yayla, Hatice G.; Wang, David Y.; Armstrong, Michael F.; Knowles, Robert R.
Journal of the American Chemical Society, 2013 , vol. 135, # 47 p. 17735 - 17738
