(2S,1'R,2'R)-pyrrolidine-2-carboxylic acid [2'-(4-methylbenzamido)-cyclohexyl]-amide; acetic acid in chloroform
T=-25°C; Aldol reaction; 72 h; Title compound not separated from byproducts;
参考文献
Font, Daniel; Jimeno, Ciril; Pericas, Miquel A.
Organic Letters, 2006 , vol. 8, # 20 p. 4653 - 4655
Mase, Nobuyuki; Nakai, Yusuke; Ohara, Naoko; Yoda, Hidemi; Takabe, Kunihiko; Tanaka, Fujie; Barbas III, Carlos F.
Journal of the American Chemical Society, 2006 , vol. 128, # 3 p. 734 - 735
1,1'-(((5,5'-((1,4-phenylenebis(azanediyl))bis(carbonyl))bis(1-((benzyloxy)carbonyl)pyrrolidine-5,3-diyl))bis(oxy))bis(5-oxopentane-5,1-diyl))bis(3-methyl-1H-imidazol-3-ium) hexafluorophosphate in water
T=20°C; Aldol Addition; 24 h; diastereoselective reaction;
参考文献
Kochetkov, Sergei V.; Kucherenko, Alexandr S.; Kryshtal, Galina V.; Zhdankina, Galina M.; Zlotin, Sergei G.
European Journal of Organic Chemistry, 2012 , # 36 p. 7129 - 7134
