Multi-step reaction with 3 steps 1.1: hydrogenchloride; KIO3; potassium iodide / methanol; water / 0 - 20 °C / Large scale reaction2.1: pyridine / 10 °C2.2: 39 - 55 °C / Large scale reaction3.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine
参考文献
Praquin, Celine F. B.; De Koning, Pieter D.; Peach, Philip J.; Howard, Roger M.; Spencer, Sarah L. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1124 - 1129