1: malonic acid dimethyl ester With triethylamine; magnesium chloride in toluene 2.5 h; light cooling; 2: 6-(trifluoromethyl)pyridine-3-carbonyl chloride in toluene 2 h; Cooling; 3: With hydrogenchloride; water more than 3 stages;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/34579 A1, 2008 ;
Location in patent: Page/Page column 24-25 ;
n-butyllithium; sodium hydride in tetrahydrofuran; hexane 48 h; Heating;
参考文献
Barrett, Anthony G. M.; Morris, Timothy M.; Barton, Derek H. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2272 - 2277