环戊基N-[3-[[2-甲氧基-4-(苯磺酰基氨基甲酰)苯基]甲基]苯并咪唑-5-基]氨基甲酸酯合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 48 h;
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
反应条件
1: 93 percent / 2,6-lutidine / CH2Cl2 / 24 h 2: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h 3: 7.4 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h View Scheme
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
反应条件
1: 26 percent / K2CO3 / butan-2-one / 24 h / Heating 2: 90 percent / SnCl2*2H2O / ethanol / 18 h / 80 °C 3: 93 percent / 2,6-lutidine / CH2Cl2 / 24 h 4: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h 5: 7.4 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h View Scheme
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
反应条件
1: 93 percent / 2,6-lutidine / CH2Cl2 / 24 h 2: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h 3: 7.4 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h View Scheme
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
反应条件
1: 26 percent / K2CO3 / butan-2-one / 24 h / Heating 2: 90 percent / SnCl2*2H2O / ethanol / 18 h / 80 °C 3: 93 percent / 2,6-lutidine / CH2Cl2 / 24 h 4: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h 5: 7.4 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h View Scheme
参考文献
Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629
