1-(4-氰基苯基)-3-苯基脲合成路线 （共 11 条）
反应条件
caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in 1,4-dioxane T=100°C; 1 h;
参考文献
Artamkina; Sergeev; Beletskaya
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 4 p. 538 - 545
反应条件
in chloroform T=50°C; 0.5 h;
参考文献
Rawling, Tristan; McDonagh, Andrew M.; Tattam, Bruce; Murray, Michael
Tetrahedron, 2012 , vol. 68, # 30 p. 6065 - 6070
反应条件
in tetrahydrofuran T=20°C;
参考文献
Zhang, Bei; Zhao, Yanfang; Zhai, Xin; Wang, Lihui; Yang, Jingyu; Tan, Zehui; Gong, Ping
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1046 - 1054
反应条件
1: benzoyl hydroxylamine With ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0°C; Lossen Rearrangement; 1.5 h; 2: p-aminobenzonitrile in tetrahydrofuran T=20°C; Lossen Rearrangement; 4 h;
参考文献
Thalluri, Kishore; Manne, Srinivasa Rao; Dev, Dharm; Mandal, Bhubaneswar
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3765 - 3775
反应条件
in dimethyl sulfoxide T=85°C; 1 h;
参考文献
Thavonekham, Bounkham
Synthesis, 1997 , # 10 p. 1189 - 1194
反应条件
1: N'-phenyl Urea With t-Bu-BippyPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) in ethylene glycol dimethyl ether T=20°C; 1 h; Inert atmosphere; 2: para-chloro-benzonitrile in ethylene glycol dimethyl ether T=85°C; 1 h; Inert atmosphere;
参考文献
Kotecki, Brian J.; Fernando, Dilinie P.; Haight, Anthony R.; Lukin, Kirill A.
Organic Letters, 2009 , vol. 11, # 4 p. 947 - 950
参考文献
Bogert; Wise
Journal of the American Chemical Society, 1912 , vol. 34, p. 701
反应条件
1: pyridine / tetrahydrofuran / 1 h / Ambient temperature 2: 87 percent / dimethylsulfoxide / 1 h / 85 °C View Scheme
参考文献
Rawling, Tristan; McDonagh, Andrew M.; Tattam, Bruce; Murray, Michael
Tetrahedron, 2012 , vol. 68, # 30 p. 6065 - 6070
反应条件
1.1: N-ethyl-N,N-diisopropylamine; ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0.5 h / 20 °C 2.1: N-ethyl-N,N-diisopropylamine; ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate / tetrahydrofuran / 1.5 h / 0 °C 2.2: 4 h / 20 °C View Scheme
参考文献
Thalluri, Kishore; Manne, Srinivasa Rao; Dev, Dharm; Mandal, Bhubaneswar
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3765 - 3775
反应条件
1: THF-d8 (tetrahydrofuran-d8) / 20 °C 2: chloroform / 0.5 h / 50 °C View Scheme
参考文献
Rawling, Tristan; McDonagh, Andrew M.; Tattam, Bruce; Murray, Michael
Tetrahedron, 2012 , vol. 68, # 30 p. 6065 - 6070
