3-(哌啶-4-基)-1H-咪唑并[4,5-b]吡啶-2(3H)-酮合成路线 （共 3 条）
反应条件
1: Zn; aq. HCl / methanol / 50 °C 2: acetonitrile 3: aq. NaOH / 100 °C View Scheme
参考文献
Henning; Lattrell; Gerhards; Leven
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 814 - 820
反应条件
1: Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 89 percent / toluene / Heating 4: 53 percent / 10percent NaOH / 8 h / Heating View Scheme
参考文献
Henning; Lattrell; Gerhards; Leven
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 814 - 820
反应条件
1: Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 89 percent / toluene / Heating 4: 53 percent / 10percent NaOH / 8 h / Heating View Scheme
参考文献
Burgey, Christopher S.; Stump, Craig A.; Nguyen, Diem N.; Deng, James Z.; Quigley, Amy G.; Norton, Beth R.; Bell, Ian M.; Mosser, Scott D.; Salvatore, Christopher A.; Rutledge, Ruth Z.; Kane, Stefanie A.; Koblan, Kenneth S.; Vacca, Joseph P.; Graham, Samuel L.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5052 - 5056
