2-(4-甲氧基苯基)-2-氧代乙醛合成路线 （共 34 条）
反应条件
1: 86 percent / acetonoxime, 2 N HCl / H2O; methanol / 2 h / 50 °C / pH 4
2: 76 percent / methanol / 120 h
3: 96 percent / NH3(g) / propan-1-ol / 36 h / Ambient temperature
4: 86 percent / Na2S2O4 / H2O / 24 h / Heating
5: 67 percent / dimethylformamide / 12 h / 160 °C
6: 45 percent / 1) 90percent aq. Na2S2O4, 0.5M NaOH, 15 min, reflux; 2) O.1M NaOH, O.1M KMnO4, r.t., 10 min
7: 87 percent / xanthine oxidase (AXO) / 120 h / 4N NaOH, potassium phosphate buffer, pH 8.0
View Scheme
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
1: 86 percent / acetonoxime, 2 N HCl / H2O; methanol / 2 h / 50 °C / pH 4
2: 76 percent / methanol / 120 h
3: 96 percent / NH3(g) / propan-1-ol / 36 h / Ambient temperature
4: 86 percent / Na2S2O4 / H2O / 24 h / Heating
5: 84 percent / acetic anhydride / 2 h / Heating
6: 86 percent / xanthine oxidase (AXO) / 120 h / 4N NaOH, potassium phosphate buffer, pH 8.0
View Scheme
参考文献
Meester, Johan W. G. De; Plas, Henk C. van der; Middelhoven, Wouter J.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 441 - 451
反应条件
ammonium acetate in methanol
T=20°C;
参考文献
Zuliani, Valentina; Cocconcelli, Giuseppe; Fantini, Marco; Ghiron, Chiara; Rivara, Mirko
Journal of Organic Chemistry, 2007 , vol. 72, # 12 p. 4551 - 4553
反应条件
ammonium acetate in methanol
T=20°C;
参考文献
Zuliani, Valentina; Fantini, Marco; Nigam, Aradhya; Stables, James P.; Patel, Manoj K.; Rivara, Mirko
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 7957 - 7965
