4-氯-3-甲氧基-2-甲基吡啶合成路线 （共 15 条）
反应条件
trichlorophosphate T=90°C; 18 h;
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 68 percent / K2CO3 / acetone / 19 h / Heating 2: 77 percent / conc. ammonia / 3 h / 110 °C 3: 85 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 2: POCl3 / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating 2: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 3: POCl3 / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / POCl3, PCl5 / 1 h / 140 °C 2: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating 3: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C 4: POCl3 / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
trichlorophosphate 1 h; Heating; Title compound not separated from byproducts;
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C 5: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
