sodium hydroxide in ethanol 0.25 h; 90 deg C bath;

1: 80.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath 2: SOCl2 / 1 h / Heating 3: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min 4: SOCl2 / 0.5 h / Ambient temperature 5: dimethylsulfoxide / 1.5 h 6: 2N NaOH / ethanol / 3 h / Heating View Scheme

1: 80.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath 2: SOCl2 / 1 h / Heating 3: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min View Scheme

Multi-step reaction with 2 steps 1: triethylamine / CHCl3 2: POCl3 / 0.5 h / 100 - 110 °C  

Multi-step reaction with 4 steps 1: 80.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath2: SOCl2 / 1 h / Heating3: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min4: SOCl2 / 0.5 h / Ambient temperature