2-溴-5-(4-氟苯基)噻吩合成路线 （共 4 条）
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=60°C;
参考文献
DENOVAMED INC.; BARDEN, Christopher, J.; HENNEBERRY, Annette, L.; BYERS, David M.; MCMASTER, Christopher, R.; WEAVER, Donald
Patent: WO2008/128321 A1, 2008 ;
Location in patent: Page/Page column 21-22 ;
反应条件
Ph3PAuOTs; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid in methanol; chloroform T=20°C;
参考文献
Ball, Liam T.; Lloyd-Jones, Guy C.; Russell, Christopher A.
Science (Washington, DC, United States), 2012 , vol. 337, # 6102 p. 1644 - 1648,5
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium chloride; sodium carbonate; triphenylphosphine in ethanol; water; toluene T=40°C; Suzuki-Miyaura Coupling; 6 h; Sealed tube;
参考文献
Minard, Corinne; Palacio, Carole; Cariou, Kevin; Dodd, Robert H.
European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2942 - 2955
反应条件
Au(OAc)3; (1S)-10-camphorsulfonic acid in chloroform-d1; methanol-d4 T=25°C; 2 h;
参考文献
Ball, Liam T.; Lloyd-Jones, Guy C.; Russell, Christopher A.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 254 - 264
