Boyd, Derek R; Sharma, Narain D; King, Alistair W T; Shepherd, Steven D; Allen, Christopher C R; Holt, Robert A; Luckarift, Heather R; Dalton, Howard
Organic and biomolecular chemistry, 2004 , vol. 2, # 4 p. 554 - 561
sodium hydride in N,N-dimethyl-formamide T=38°C; 24 h;
参考文献
Perez-Encabo, Alfonso; Perrio, Stephane; Slawin, Alexandra M. Z.; Thomas, Susan E.; Wierzchleyski, Adam T.; Williams, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 629 - 642
1: 85 percent / KF, alumina / acetonitrile / 12 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) a) from -78 deg C to RT, b) RT, 24 h
3: 61 percent / aq. HCl / tetrahydrofuran / 6 h / 60 °C
4: 82 percent / aq. KOH / ethanol / 3.5 h / Heating
View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
1: 86 percent / NaH / dimethylformamide / 24 h / 38 °C
2: 94 percent / mCPBA / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) room temperature, 2 h
View Scheme
参考文献
Perez-Encabo, Alfonso; Perrio, Stephane; Slawin, Alexandra M. Z.; Thomas, Susan E.; Wierzchleyski, Adam T.; Williams, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 629 - 642
