4,4-二甲基-2-环己基-1-酮合成路线 （共 63 条）
反应条件
Yield given. Multistep reaction;
参考文献
Rao, Jampani Madhusudana; Schuster, David I.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, p. 114 - 116
反应条件
1: LiAlH4
2: Zn-Cu
3: CrO3, Py
View Scheme
参考文献
Russell,G.A. et al.
Journal of the American Chemical Society, 1971 , vol. 93, # 6 p. 1452 - 1466
反应条件
n-butyllithium; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; triethylamine; lithium diisopropyl amide
2.) -40 deg C; 3.) r.t.; Yield given. Multistep reaction;
参考文献
Sugimura, Takashi; Futagawa, Tohru; Katagiri, Toshifumi; Nishiyama, Norio; Tai, Akira
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7303 - 7306
反应条件
1: 82 percent / H2 / 5percent Pd/C / pentane / 5 °C
2: 93 percent / KO-t-Bu / 2-methyl-propan-2-ol / 8 h / 45 °C
3: 75 percent / DDQ / 0.08 h
4: 1.) NaH / 1.) Me2SO, 15 min
5: H2 / 30percent Pd/C / ethyl acetate; pyridine / 3 h
6: 1.) TsOH*H2O, 2.) PyHBr3 / 1.) AcOH, reflux, 80 min, 2.) 30 min
7: 80 percent / H2, conc, H2SO4 / 10percent Pd/C / ethanol / 36 h
View Scheme
参考文献
Meyer, Walter L.; Brannon, Michael J.; Burgos, Celmira da G.; Goodwin, Thomas E.; Howard, Ralph W.
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 438 - 447
反应条件
18-crown-6 ether in benzene
5 h; Ambient temperatureother 4,4- and 5,5-disubstituted-2-en-1-ones, var. base reagents; Product distributionMechanism;
参考文献
Frimer, Aryeh A.; Gilinsky-Sharon, Pessia; Aljadeff, Gladis; Gottlieb, Hugo E.; Hameiri-Buch, Judith; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4853 - 4866
反应条件
1: palladium monocarbide / ethyl acetate
2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water
View Scheme
参考文献
Smithkline Beecham Corporation
Patent: US2011/124559 A1, 2011 ;
反应条件
potassium hydroxide; hydrogen; RuCl2lt;(S)-binapgt;(dmf)n*(R,R)-1,2-diphenylethylenediamine in isopropyl alcohol
T=28°C; P=3040 Torr; 2 h;
参考文献
Ohkuma, Takeshi; Ikehira, Hideyuki; Ikariya, Takao; Noyori, Ryoji
Synlett, 1997 , # SPEC. ISS. p. 467 - 468
反应条件
1: With [2-(methoxymethy)phenyl]phenylsilane; RhCl(PPh3)3
T=20°C;
2: With hydrogenchloride
参考文献
Imao, Daisuke; Hayama, Miyuki; Ishikawa, Kohta; Ohta, Tetsuo; Ito, Yoshihiko
Chemistry Letters, 2007 , vol. 36, # 3 p. 366 - 367
反应条件
sodium tetrahydroborate; Nd(EBAB)Cl3 in methanol
1 h; Ambient temperatureother reagents: Ce(EBAB)Cl3, Pr(EBAB)Cl3, Yb(PBAB)Cl3,; Product distribution;
参考文献
Swamy, S. Jagannatha; Kumar, B. Kishore
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 5 p. 484 - 486
反应条件
lithium aluminium tetrahydride; 4,7,13,18-tetraoxa-1,10-diazabicyclo[8.5.5]eicosane in tetrahydrofuran
1 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Aramini, Andrea; Brinchi, Lucia; Germani, Raimondo; Savelli, Gianfranco
European Journal of Organic Chemistry, 2000 , # 9 p. 1793 - 1797
