丙二酸单乙酯合成路线

参考文献

Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Maleczka, Robert E.; Nordeen, Carl W.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 504 - 509

1071-46-1丙二酸单乙酯

94695-50-8左氧氟单酯

参考文献

Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575

1071-46-1丙二酸单乙酯+

933-88-0邻甲基苯甲酰氯

51725-82-7(2-甲基苯甲酰)乙酸乙酯

参考文献

Brown; Coulston; Eastwood; Moffat
Tetrahedron, 1992 , vol. 48, # 36 p. 7763 - 7774

1071-46-1丙二酸单乙酯+

7732-18-5水

924-44-7乙醛酸乙酯

参考文献

Hickling; Westwood
Journal of the Chemical Society, 1938 , p. 1039
Journal of the Chemical Society, 1939 , p. 1110

参考文献

Hickling; Westwood
Journal of the Chemical Society, 1938 , p. 1039
Journal of the Chemical Society, 1939 , p. 1110

58757-38-36-氯烟酰氯+

1071-46-1丙二酸单乙酯

216317-64-53-(6-氯吡啶-3-基)-3-氧代丙酸乙酯

参考文献

VIROBAY, INC.
Patent: WO2007/5779 A2, 2007 ;
Location in patent: Page/Page column 38 ;

194804-99-43-(4-溴-2-氟-3-甲氧基苯基)-3-氧代丙酸乙酯

参考文献

Wang, Qiuping; Lucien, Edlaine; Hashimoto, Akihiro; Pais, Godwin C. G.; Nelson, David M.; Song, Yongsheng; Thanassi, Jane A.; Marlor, Christopher W.; Thoma, Christy L.; Cheng, Jijun; Podos, Steven D.; Ou, Yangsi; Deshpande, Milind; Pucci, Michael J.; Buechter, Douglas D.; Bradbury, Barton J.; Wiles, Jason A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 199 - 210

1071-46-1丙二酸单乙酯+

100-61-8N-甲基苯胺

21911-74-0

参考文献

Zhang, Jie; Jiang, Jiewen; Li, Yuling; Zhao, Yun; Wan, Xiaobing
Organic Letters, 2013 , vol. 15, # 13 p. 3222 - 3225

1071-46-1丙二酸单乙酯+

999-97-3六甲基二硅氮烷

18457-03-9乙基三甲基硅基丙二酸

参考文献

Bruynes, Cornelis A.; Jurriens, Theodorus K.
Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3966 - 3969

75-77-4三甲基氯硅烷+

1071-46-1丙二酸单乙酯

18457-03-9乙基三甲基硅基丙二酸

参考文献

Guzman-Perez, Angel; Wester, Ronald T.; Allen, Mary C.; Brown, Janice A.; Buchholz, Allan R.; Cook, Ewell R.; Day, Wesley W.; Hamanaka, Ernest S.; Kennedy, Scott P.; Knight, Delvin R.; Kowalczyk, Paul J.; Marala, Ravi B.; Mularski, Christian J.; Novomisle, William A.; Ruggeri, Roger B.; Tracey; Hill, Roger J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 803 - 807