1: With triethylamine; trichlorophosphate in dichloromethane T=0 - 26°C; 1 h; Inert atmosphere; 2: With hydrogenchloride; water T=0°C; 2 h; Reflux; 3: With triethylamine in water T=18 - 26°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: US2010/317624 A1, 2010 ;
Location in patent: Page/Page column 61 ;
US 20100317624 A1