1-(Boc-氨基)环丙基甲醇合成路线 （共 18 条）
反应条件
lithium borohydride in tetrahydrofuran Ambient temperature;
参考文献
Wentland; Perni; Dorff; Rake
Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1694 - 1697
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-70 - -5°C; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether T=-15 - 20°C; 3: With water in ethylene glycol dimethyl ether
参考文献
US2010/305102 A1, ;
Page/Page column 16 ;
US 20100305102 A1
反应条件
hydrogen; palladium on activated charcoal in methanol Hydrogenolysis; P=750.06 Torr;
参考文献
Kordes, Markus; Winsel, Harald; De Meijere, Armin
European Journal of Organic Chemistry, 2000 , # 18 p. 3235 - 3245
反应条件
titanium(IV) isopropylate in diethyl ether T=0°C; Inert atmosphere;
参考文献
Pearson-Long, Morwenna S.M.; Beauseigneur, Alice; Karoyan, Philippe; Szymoniak, Jan; Bertus, Philippe
Synthesis, 2010 , # 20 art. no. T13410SS, p. 3410 - 3414
反应条件
lithium borohydride in tetrahydrofuran
参考文献
Charton, Yves; Guillonneau, Claude; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2188 - 2193
反应条件
sodium tetrahydroborate; water in ethylene glycol dimethyl ether T=0°C; 0.166667 h;
参考文献
WO2009/70485 A1, ;
Page/Page column 124 ;
WO 2009/070485 A1
反应条件
1: With lithium borohydride in tetrahydrofuran T=0 - 20°C; 2: With methanol in tetrahydrofuran T=0°C; 0.166667 h;
参考文献
WO2011/119759 A1, ;
Page/Page column 132 ;
反应条件
4-methyl-morpholine; sodium borohydride in ethylene glycol dimethyl ether; water
反应条件
1: 94 percent / NaOH / 2-methyl-propan-2-ol; H2O / 1 h 2: 97 percent / H2 / 5percent Pd/C / methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 11 p. 3965 - 3968
反应条件
in sodium hydrogencarbonate; tert-butyl alcohol
