向内-N-(9-甲基-9-氮杂双环[3.3.1]壬烷-3基)-1H-吲唑-3-甲酰胺合成路线 （共 3 条）
反应条件
1: 1H-indazole-3-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane; N,N-dimethyl-formamide T=20°C; 2 h; 2: (endo)-3-amino-9-methyl-9-azabicyclo[3.3.1]nonane in dichloromethane; N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestr, Linda; Lummis, Sarah C. R.; Lochner, Martin
Journal of Medicinal Chemistry, 2010 , vol. 53, # 5 p. 2324 - 2328
反应条件
in N,N-dimethyl-formamide
反应条件
in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Bermudez, Jose; Fake, Charles S.; Joiner, Graham F.; Joiner, Karen A.; King, Frank D.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1924 - 1929
