N,N-二甲基-1-(6-甲基-2-(对甲苯)咪唑并[1,2-a]吡啶-3-基)甲胺合成路线 （共 5 条）
反应条件
1: With acetic acid in water T=0 - 55°C; 3 - 4 h; 2: With sodium hydroxide; water pH=8 - 8.5; Product distribution / selectivity;
参考文献
SUVEN LIFE SCIENCES LIMITED
Patent: WO2009/7995 A1, 2009 ;
Location in patent: Page/Page column 11; 13-14; 15-17 ;
反应条件
1.1: MeI / ethanol / 24 h / 20 °C 1.2: H2O; ethanol / 4 h / Heating 2.1: 87 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
George; Rossey; Depoortere; Mompon; Allen
Farmaco, 1991 , vol. 46, # SUPPL. 1 p. 277 - 288
反应条件
1.1: MeI / ethanol / 24 h / 20 °C 1.2: H2O; ethanol / 4 h / Heating 2.1: 87 percent / aq. KOH / ethanol / 8 h / Heating 3.1: tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
George; Rossey; Depoortere; Mompon; Allen
Farmaco, 1991 , vol. 46, # SUPPL. 1 p. 277 - 288
反应条件
1: dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine With methyl iodide in ethanol T=20°C; 24 h; 2: potassium cyanide in ethanol; water 4 h; Heating;
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
参考文献
George; Rossey; Depoortere; Mompon; Allen
Farmaco, 1991 , vol. 46, # SUPPL. 1 p. 277 - 288
