2-溴-N,N-二乙基乙胺 氢溴酸盐合成路线 （共 8 条）
反应条件
hydrogen bromide; phosphorus tribromide T=140°C; Bromination; 11 h;
参考文献
European Journal of Inorganic Chemistry, , # 9 p. 1715 - 1726
反应条件
sodium hydrogensulfide; ethanol
参考文献
Lischer; Jordan
Journal of the American Chemical Society, 1937 , vol. 59, p. 1623
参考文献
Shklyaev,V.S.; Pantsurkin,V.I.
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, p. 1182 - 1184,1218 - 1220
参考文献
Journal of the American Pharmaceutical Association (1912-1977), , vol. 25, p. 501,503
反应条件
NaH in tetrahydrofuran; hexane; ethyl acetate
反应条件
triethylamine in dichloromethane
T=20°C; 5 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/6569 A1, 2009 ;
Location in patent: Page/Page column 45 ;
WO 2009/006569 A1
反应条件
water; sodium carbonate in ethyl acetate
参考文献
Cai, Zhenhong R.; Jabri, Salman Y.; Jin, Haolun; Lansdown, Rachael A.; Metobo, Samuel E.; Mish, Michael R.; Pastor, Richard M.
Patent: US2008/58315 A1, 2008 ;
Location in patent: Page/Page column 61 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine in toluene
T=20°C; 5 h;
2: With sodium hydrogencarbonate in water; ethyl acetate; toluene
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/6569 A1, 2009 ;
Location in patent: Page/Page column 42 ;
WO 2009/006569 A1
