3-氨基-2-溴苯甲酸甲酯合成路线 （共 10 条）
反应条件
tin(ll) chloride in methanol; water 2 h; Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2004/63198 A1, 2004 ;
Location in patent: Page 77 ;
WO 2004/063198 A1
参考文献
Eli Lilly and Company
Patent: US6177440 B1, 2001 ;
反应条件
1: 1.) hydrobromic acid, sodium nitrite, 2.) coopper(I) bromide / 1.) water, 1,4-dioxane, 0 deg C, 15 min, 2.) a) 0 deg C, 15 min, b) 60 deg C,15 min 2: 15 percent / potasium permanganate / H2O / 5 h / Heating 3: 86 percent / iron / ethanol; acetic acid / 3.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1170 - 1176
反应条件
1: 15 percent / potasium permanganate / H2O / 5 h / Heating 2: 86 percent / iron / ethanol; acetic acid / 3.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1170 - 1176
反应条件
N-bromosuccinmide in dimethyl sulfoxide T=20°C;
参考文献
Synthesis, , # 8 art. no. P12608SS, p. 1305 - 1308
反应条件
N-bromosuccinmide in DCE T=20°C;
参考文献
Synthesis, , # 8 art. no. P12608SS, p. 1305 - 1308
反应条件
1.1: PCl5 / 0.08 h / 150 °C 1.2: 94 percent / 1 h / Heating 2.1: 87 percent / glacial acetic acid; iron / 2 h / 120 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 2 p. 165 - 173
反应条件
triethylamine; palladium diacetate; tris-(o-tolyl)phosphine in acetonitrile T=100°C; 20 h; sealed tube;
参考文献
Kasahara, Akira; Izumi, Taeko; Kikuchi, Tokio; Xiao-ping Lin
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1555 - 1556
反应条件
1: methyl 2-bromo-3-aminobenzoate With tert.-butylnitrite; boron trifluoride diethyl etherate in diethyl ether; dichloromethane T=-15 - 5°C; Diazotization; 2: propane-1-thiol With triethylamine in acetonitrile T=80°C; Alkylation; substitution; decomposition; deamination; 18 h;
参考文献
Sienkowska, Monika; Benin, Vladimir; Kaszynski, Piotr
Tetrahedron, 2000 , vol. 56, # 2 p. 165 - 173
反应条件
1: 91 percent / BF3*Et2O; t-butyl nitrite / CH2Cl2; diethyl ether / -15 - 5 °C 2: triethylamine / acetonitrile / 18 h / 80 °C View Scheme
参考文献
Sienkowska, Monika; Benin, Vladimir; Kaszynski, Piotr
Tetrahedron, 2000 , vol. 56, # 2 p. 165 - 173
