3-甲基-4-(三氟甲基)苯胺合成路线 （共 3 条）
反应条件
2-picoline; Na2S2O5; sulfur dioxide; zinc in N,N-dimethyl-formamide T=20°C; P=2250.2 - 3750.3 Torr; 2 h;
参考文献
Tordeux, Marc; Langlois, Bernard; Wakselman, Claude
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 8 p. 2293 - 2299
反应条件
1: 95 percent / Cu / dimethylformamide / 5 h / 150 °C 2: 93 percent / H2 / 5percent Pd/C / methanol / 937.6 Torr View Scheme
参考文献
ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew
Patent: WO2013/96771 A1, 2013 ;
反应条件
1: 1.) H2SO4, aq. NaNO2, 2.) KI / 1.) from 0 to 5 deg C, 2.) a.) H2O, RT, 2 h, b.) from 50 to 60 deg C, 1 h 2: 95 percent / Cu / dimethylformamide / 5 h / 150 °C 3: 93 percent / H2 / 5percent Pd/C / methanol / 937.6 Torr View Scheme
参考文献
ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew
Patent: WO2013/96771 A1, 2013 ;
