2-甲基-4-(三氟甲基)吡啶合成路线 （共 3 条）
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; hexanes 2.5 h; Heating / reflux; 2: With hydrogenchloride in 1,4-dioxane; hexanes; water T=0°C;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2007/31747 A1, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/031747 A1
反应条件
in N,N-dimethyl-formamide T=100°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Mormino, Michael G.; Fier, Patrick S.; Hartwig, John F.
Organic Letters, 2014 , vol. 16, # 6 p. 1744 - 1747
反应条件
Na2S2O5; sulfur dioxide; zinc in N,N-dimethyl-formamide T=65°C; P=5250.4 - 6000.5 Torr; 3 h;
参考文献
Tordeux, Marc; Langlois, Bernard; Wakselman, Claude
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 8 p. 2293 - 2299
