1-(S)-顺式-9-氨基八氢-10-氧代-6H-吡嗪并[1,2-a][1,2]二氮杂卓-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
hydrazine hydrate in ethanol 1 h; Ambient temperature;
参考文献
RANBAXY LABORATORIES LIMITED; KUMAR, Harish; PAREKH, Amar; ARORA, Sanjeev Kumar; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan
Patent: WO2012/49646 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: NaHCO3 / toluene; H2O / 17 h / Ambient temperature 2: H2 / 5percent Pd-C / dimethylformamide / 18 h 3: SOCl2 / CH2Cl2 / 4 h / Ambient temperature 4: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 5: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: H2 / 5percent Pd-C / dimethylformamide / 18 h 2: SOCl2 / CH2Cl2 / 4 h / Ambient temperature 3: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 4: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: NaHCO3 / toluene; H2O / 17 h / Ambient temperature 2: H2 / 5percent Pd-C / dimethylformamide / 18 h 3: SOCl2 / CH2Cl2 / 4 h / Ambient temperature 4: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 5: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: SOCl2 / toluene 2: NaHCO3 / toluene; H2O / 17 h / Ambient temperature 3: H2 / 5percent Pd-C / dimethylformamide / 18 h 4: SOCl2 / CH2Cl2 / 4 h / Ambient temperature 5: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 6: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: SOCl2 / CH2Cl2 / 4 h / Ambient temperature 2: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 3: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; KUMAR, Harish; PAREKH, Amar; ARORA, Sanjeev Kumar; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan
Patent: WO2012/49646 A1, 2012 ;
反应条件
1: 90 percent / 1M borane in THF / tetrahydrofuran / 3 h / Ambient temperature 2: hydrazine hydrate / ethanol / 1 h / Ambient temperature View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; KUMAR, Harish; PAREKH, Amar; ARORA, Sanjeev Kumar; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan
Patent: WO2012/49646 A1, 2012 ;
反应条件
1: 10percent aq. Na2CO3 / CH2Cl2 / 5 h / Ambient temperature 2: 91 percent / HCl / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
