2'-脱氧-肌苷 3',5'-二乙酸酯合成路线 （共 10 条）
反应条件
chloro-trimethyl-silane; BnEt3NNO2 in dichloromethane T=0°C;
参考文献
Francom, Paula; Robins, Morris J.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 666 - 669
反应条件
sodium hydride in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Mola, Laura; Font, Joan; Bosch, Lluis; Caner, Joaquim; Costa, Anna M.; Etxebarria-Jardi, Gorka; Pineda, Oriol; De Vicente, David; Vilarrasa, Jaume
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 5832 - 5842
反应条件
tert.-butylnitrite; trimethylsilyl bromide; 1,1-dibromomethane T=0 - 5°C;
参考文献
Francom, Paula; Robins, Morris J.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 666 - 669
反应条件
in pyridine 12 h; Ambient temperature;
参考文献
Kamaike; Takahashi; Utsugi; Tomizuka; Okazaki; Tamada; Kinoshita; Masuda; Ishido
Nucleosides and Nucleotides, 1996 , vol. 15, # 1-3 p. 749 - 769
反应条件
1: 87 percent / adenosine deaminase (EC 3.5.4.4) 2: 85 percent / pyridine / 2 h / Ambient temperature View Scheme
参考文献
Seela; Herdering; Kehne
Helvetica Chimica Acta, 1987 , vol. 70, # 6 p. 1649 - 1660
反应条件
1: 90 percent / Ph3P, DBU / CCl4; CH2Cl2 / 0.67 h / Heating 2: 64 mg / 15 h / 50 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 923 - 926
反应条件
1: 84 percent / NaH / tetrahydrofuran 2: 28 percent / NaOH / ethanol / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 2 p. 288 - 295
反应条件
1: 2-chlorophenyl dichlorophosphate / Ambient temperature 2: thiolacetic acid / dioxane; H2O / 0 °C 3: 1M NaOH View Scheme
参考文献
Xu, Yao-Zhong; Zheng, Qinguo; Swann, Peter F.
Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5837 - 5840
反应条件
1: 84 percent / NaH / tetrahydrofuran
2: 28 percent / NaOH / ethanol / Heating
3: pyridine / 24 h / Ambient temperature
4: K2CO3, 18-crown-6-ether / dimethylformamide / 36 h / 40 °C
5: 5N NaOH / ethanol / 0.83 h / Heating
6: TFA / CH2Cl2 / 3 h / Ambient temperature
7: 98 percent / imidazole / dimethylformamide / 14 h / Ambient temperature
8: 97 percent / p-toluenesulfonyl chloride, pyridine / 24 h / Heating
9: 55 percent / isoamyl nitrite, CH2I2 / 0.33 h / 100 °C
10: (PhCN)2PdCl2 / acetonitrile / 14 h / 100 °C
11: NH3 / methanol
12: 70 percent / NH3 / methanol / 12 h / 120 °C
13: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Minakawa; Sasabuchi; Kiyosue; Kojima; Matsuda
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 2 p. 288 - 295
反应条件
1: 91 percent / K2CO3 / dimethylformamide / 2.5 h / 80 °C
2: 94 percent / ethylenediamine / 4 h / 50 °C
View Scheme
参考文献
Minakawa; Sasabuchi; Kiyosue; Kojima; Matsuda
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 2 p. 288 - 295
