6-氟-2,3-二氢-1H-吲哚-1-羧酸,1,1-二甲基乙酯合成路线 （共 4 条）
反应条件
triethylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
Location in patent: Page/Page column 127 ;
WO 2008/118724 A1
反应条件
1: N,N-dimethyl-formamide / Inert atmosphere; Reflux 2: water; methanol / 1 h / 20 °C / Inert atmosphere 3: hydrogen; ferrous acetate / 5 rhodium-on-charcoal / toluene; tetrahydrofuran / 48 h / 20 °C / 38002.6 Torr / Inert atmosphere 4: hydrogenchloride; Et3N-BH3 / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux 5: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
1: hydrogen; ferrous acetate / 5 rhodium-on-charcoal / toluene; tetrahydrofuran / 48 h / 20 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride; Et3N-BH3 / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux 3: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
反应条件
1: hydrogenchloride; Et3N-BH3 / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/118724 A1, 2008 ;
WO 2008/118724 A1
