triethylamine; sodium iodide in N,N-dimethyl-formamide Ambient temperature;

1: thionyl chloride 2: benzene View Scheme

in benzene

hydrogenchloride half-lives of ester hydrolysis in 50percent human plasma, pH 7.40; pH (2 - 12) -rate profiles for the degradation of title compound in aq. solution at 60 - 90 deg C; t10percent = 5 years; activation energy = 20.3 kcal/mol; Rate constant;

potassium hydroxide in ethanol 1 h; Ambient temperature;

1: aq. NaOH / half-lives of ester hydrolysis in 50percent human plasma, pH 7.40; pH (2 - 12) -rate profiles for the degradation of title compound in aq. solution at 30 - 60 deg C; t10percent = 5 years; activation energy = 14.3 kcal/mol 2: NaI, Et3N / dimethylformamide / Ambient temperature View Scheme

1: aq. NaOH / half-lives of ester hydrolysis in 50percent human plasma, pH 7.40; pH (2 - 12) -rate profiles for the degradation of title compound in aq. solution at 30 - 60 deg C; t10percent = 5 years; activation energy = 14.3 kcal/mol 2: NaI, Et3N / dimethylformamide / Ambient temperature View Scheme

potassium hydroxide in ethanol 1 h; Ambient temperature;

human plasma solution; water T=37°C; Rate constant;