4-(4-氧代丁基)苯甲酸甲酯合成路线 （共 16 条）
反应条件
tetrabutyl-ammonium chloride; lithium chloride; palladium diacetate in N-methyl-acetamide; water; ethyl acetate; acetonitrile
参考文献
Eli Lilly and Company
Patent: US6013828 A1, 2000 ;
反应条件
anhydrous lithium acetate; tetrabutylammomium bromide; lithium chloride; palladium diacetate in N,N-dimethyl-formamide T=60°C; 10 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Li, Jinliang; Zhao, Nan
Patent: US2011/124861 A1, 2011 ;
Location in patent: Page/Page column 3 ;
反应条件
sodium acetate; pyridinium chlorochromate in dichloromethane T=20°C; 3 h;
参考文献
Taylor, Edward C.; Liu, Bin
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9938 - 9947
反应条件
hydrogen; palladium in ethanol
参考文献
The Trustees of Princeton University
Patent: US6066732 A1, 2000 ;
反应条件
sodium acetate; pyridinium chlorochromate in dichloromethane
参考文献
The Trustees of Princeton University
Patent: US6066732 A1, 2000 ;
反应条件
1: 97 percent / H2 / Pd/C / ethanol / 18 h / 2585.74 Torr 2: 90 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Barnett, Charles J.; Wilson, Thomas M.; Kobierski, Michael E.
Organic Process Research and Development, 1999 , vol. 3, # 3 p. 184 - 188
反应条件
hydrogenchloride in tetrahydrofuran T=40°C; 15 h;
参考文献
DeGraw; Tagawa; Christie; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 1 - 4
反应条件
1: 76 percent / palladium chloride, triphenylphosphine, copper(I) iodide, diethylamine / 18 h / Ambient temperature 2: 100 percent / hydrogen / 5percent Pd/C / ethanol / 12 h / 2585.7 Torr 3: 60 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 12 h / Ambient temperature View Scheme
参考文献
Barnett, Charles J.; Wilson, Thomas M.; Kobierski, Michael E.
Organic Process Research and Development, 1999 , vol. 3, # 3 p. 184 - 188
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 90 percent / tetrahydrofuran / 1 h / 0 °C 2.1: H2 / Pd/C / methanol / 0.5 h / 20 °C / 760 Torr 3.1: 99 percent / PPTS / acetone; H2O / 12 h / Heating View Scheme
参考文献
Ohno, Hiroaki; Okumura, Mitsuaki; Maeda, Shin-Ichiro; Iwasaki, Hiroki; Wakayama, Ryutaro; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7722 - 7732
反应条件
1: With copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride T=50°C; 4 h; 2: With 10 palladium on activated charcoal; hydrogen in dichloromethane P=2585.81 Torr; 3.5 h; 3: With sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hydrogencarbonate; potassium bromide in dichloromethane T=-10 - 0°C; 1 h;
参考文献
Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144
