2-(4-溴苯基)-1,3-二氧戊环合成路线 （共 37 条）
反应条件
magnesium in tetrahydrofuran
参考文献
Japan Tobacco Inc.
Patent: EP885869 A1, 1998 ;
反应条件
diiodo monosilane in chloroform-d1 T=-42°C; 0.0166667 h;
参考文献
Keinan, E.; Perez, D.; Sahai, M.; Shvily, R.
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2927 - 2938
反应条件
in chloroform T=25°C; 10 h;
参考文献
Li, Wei; Li, Jianchang; Wu, Yuchuan; Fuller, Nathan; Markus, Michelle A.
Journal of Organic Chemistry, 2010 , vol. 75, # 4 p. 1077 - 1086
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: With tributoxyborane in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
Wu, Zhisheng; An, Zhongwei; Chen, Xinbing; Chen, Pei
Organic Letters, 2013 , vol. 15, # 7 p. 1456 - 1459
反应条件
n-butyllithium in tetrahydrofuran; hexane T=20°C; 2 h; Inert atmosphere;
参考文献
Wu, Difeng; Shao, Tao; Men, Jian; Chen, Xiaochuan; Gao, Guowei
Dalton Transactions, 2014 , vol. 43, # 4 p. 1753 - 1761
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating 1.2: tetrahydrofuran / 2 h / Heating 2.1: aq. HCl; acetone / 0.5 h / 20 °C 3.1: acetic acid; pyrrolidine / benzene / 2 h / Heating View Scheme
参考文献
Shiba, Kazuhiro; Ogawa, Kazuma; Ishiwata, Kiichi; Yajima, Kazuyoshi; Mori, Hirofumi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2620 - 2626
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating 1.2: tetrahydrofuran / 2 h / Heating 2.1: aq. HCl; acetone / 0.5 h / 20 °C 3.1: acetic acid; pyrrolidine / benzene / 2 h / Heating 4.1: sodium hydride / tetrahydrofuran / 0.58 h 4.2: tetrahydrofuran / 13.5 h 5.1: aq. HCl / 60 h / Heating 6.1: thionyl chloride / 17.5 h 7.1: urea; NaOEt / ethanol / 17 h / Heating 8.1: borane-tetrahydrofuran / tetrahydrofuran / 19 h / Heating View Scheme
参考文献
Shiba, Kazuhiro; Ogawa, Kazuma; Ishiwata, Kiichi; Yajima, Kazuyoshi; Mori, Hirofumi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2620 - 2626
反应条件
1: With magnesium in tetrahydrofuran 24 h; Reflux; 2: With Ni(PPh3)3Cl2 in tetrahydrofuran; benzene 72 h; Reflux;
参考文献
Mostovich, Evgeny A.; Borozdina, Yulia; Enkelmann, Volker; Removic-Langer, Katarina; Wolf, Bernd; Lang, Michael; Baumgarten, Martin
Crystal Growth and Design, 2012 , vol. 12, # 1 p. 54 - 59
反应条件
1: 2-(4'-bromophenyl)-1,3-dioxolane With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.416667 h; Inert atmosphere; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; 20 h; Inert atmosphere;
参考文献
Shintani, Ryo; Ito, Tomoaki; Hayashi, Tamio
Organic Letters, 2012 , vol. 14, # 9 p. 2410 - 2413
反应条件
1: (i) Mg, THF, (ii) /BRN= 1900390/, (iii) aq. H2SO4 2: NaOAc / 10 h / 150 - 160 °C / Heating View Scheme
参考文献
Landgrebe,J.A.; Rynbrandt,R.H.
Journal of Organic Chemistry, 1966 , vol. 31, p. 2585 - 2593
