water; sodium hydroxide in methanol T=0 - 20°C; 5 h;

potassium hydroxide in methanol T=25°C; 24 h;

copper in quinoline T=110°C; 1 h;

1: sulfuric acid / 30 h / |Reflux 2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C 3: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C View Scheme

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C 2: sodium hydroxide; water / methanol / 5 h / 0 - 20 °C View Scheme

thionyl chloride in Ar

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C 2: toluene-4-sulfonic acid / methanol / 12 h / 20 °C 3: copper(II) sulfate; TBTA; sodium L-ascorbate / water; methanol / 24 h / 20 °C / |Combinatorial reaction / High throughput screening (HTS) View Scheme