3,3-二乙氧基丙酸乙酯合成路线 （共 81 条）
反应条件
1: 80 percent / hydrazine hydrate / 2.5 h / Heating 2: aq. HCl, NaNO2 / CHCl3 / 0.25 h / -5 °C 3: CHCl3 / Heating 4: 77 percent / (C2H5)3N / CHCl3 / 0.75 h / 20 °C View Scheme
参考文献
Bock, Veronika; Kloetzer, Wilhelm; Singewald, Nicolas; Strieder, Georg
Synthesis, 1987 , # 12 p. 1058 - 1060
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
参考文献
Daicel Chemical Industries, Ltd.
Patent: US2007/197806 A1, 2007 ;
Location in patent: Page/Page column 8 ;
反应条件
sodium hydroxide; water in tetrahydrofuran
T=20°C; 12 h;
参考文献
Mitsubishi Pharma Corporation
Patent: EP1426366 A1, 2004 ;
Location in patent: Page 31-32 ;
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
反应条件
sodium hydrogen sulphate
参考文献
Croxall et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2741
反应条件
titanium(IV) isopropylate in tetrahydrofuran; diethyl ether
T=20°C; Kulinkovich reaction; 18 h;
参考文献
Limbach, Michael; Dalai, Suryakanta; De Meijere, Armin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 760 - 766
反应条件
oxygen; ytterbium(III) triflate in toluene
T=90°C; P=760.051 Torr;
参考文献
Sueki, Shunsuke; Takei, Ryo; Abe, Junya; Shimizu, Isao
Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4473 - 4477
