1: 4-(2-propenoxy)phenol With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h; Inert atmosphere;
2: epichlorohydrin in tetrahydrofuran
T=0 - 20°C; Inert atmosphereReflux;
参考文献
Chavez, Sherry A.; Martinko, Alexander J.; Lau, Corinna; Pham, Michael N.; Cheng, Kui; Bevan, Douglas E.; Mollnes, Tom E.; Yin, Hang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4659 - 4669
copper (I) cyanide in tetrahydrofuran; diethyl ether
T=-50°C; 3 h;
参考文献
Bergeron, Philippe; Farthing, Christopher N.; Jones, Stuart D.; Liebeschuetz, John W.; Lively, Sarah E.; McGee, Lawrence R.; McKendry, Sharon; Sheppard, David; Young, Stephen C.
Patent: US2006/84802 A1, 2006 ;
Location in patent: Page/Page column 35 ;
US 20060084802 A1