1: octadecanyl bromide With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: (S)-(+)-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-methanol in tetrahydrofuran T=0 - 20°C; 10 h;

sodium hydride in N,N-dimethyl-formamide; Petroleum ether T=50°C; 3 h;

暂无反应条件数据

暂无反应条件数据

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 8: 68.7 percent / pyridine / 72 h / Ambient temperature 9: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 10: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 11: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 12: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 8: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 9: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 78 percent / pyridine / CH2Cl2 / 50 °C 3: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 8: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme