4-二乙氨基-2-丁炔-1-醇合成路线 （共 18 条）
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: With sulfuric acid T=65 - 70°C; 2 h; 2: With sodium hydrogencarbonate in dichloromethane; water Saturated solution;
参考文献
MATRIX LABORATORIES LIMITED
Patent: WO2009/122429 A2, 2009 ;
Location in patent: Page/Page column 6 ;
参考文献
Waters,J.A.; Wiese,G.A.
Journal of the American Pharmaceutical Association, Scientific Edition, 1960 , vol. 49, p. 112 - 114
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: With dimethyl sulfate in diethyl ether
2 h; Heating;
2: With lithium aluminium tetrahydride in diethyl ether
5 h; Heating; Further stages.;
参考文献
Wang, San-yong; Mao, Wei-wei; She, Zhi-gang; Li, Chun-rong; Yang, Ding-qiao; Lin, Yong-cheng; Fu, Li-wu
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2785 - 2788
反应条件
Hydrogenation.katalytische Hydrierung;
参考文献
Kruglikova,R.I.; Kalinina,G.R.
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, p. 894 - 897,910 - 912
反应条件
1: 84 percent / diethyl ether / Heating
2: NaH / 1.) THF, reflux, 1 h, 2.) room temperature
View Scheme
参考文献
Schmid, Rudolf; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1990 , vol. 73, p. 1258 - 1275
