1-N-苄氧羰基-2-羟甲基哌啶合成路线 （共 17 条）
反应条件
potassium carbonate in tetrahydrofuran T=65°C; 0.166667 h; microwave irradiation;
参考文献
Azzena, Ugo; Dettori, Giovanna; Pisano, Luisa; Pittalis, Mario
Synthetic Communications, 2007 , vol. 37, # 20 p. 3623 - 3634
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0 - 20°C;
参考文献
WO2008/125570 A1, ;
Page/Page column 35 ;
WO 2008/125570 A1
反应条件
sodium tetrahydroborate in methanol; tert-butyl alcohol 0.5 h; Heatingultrasonic irradiation;
参考文献
Nurdinov, R.; Liepin'sh, E. E.; Kalvin'sh, I. Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 11 p. 1352 - 1357
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 11 p. 1567 - 1573
反应条件
1: NEt3 2: NaBH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 48 p. 8759 - 8763
反应条件
1: NEt3 2: NaBH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 48 p. 8759 - 8763
反应条件
1: NEt3 2: NaBH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 48 p. 8759 - 8763
反应条件
1: N(C2H5)3 / tetrahydrofuran / 1 h / Ambient temperature 2: 100 percent / NaBH4 / methanol; 2-methyl-propan-2-ol / 0.5 h / Heating; ultrasonic irradiation View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 29, # 11 p. 1352 - 1357
Khimiya Geterotsiklicheskikh Soedinenii, , # 11 p. 1567 - 1573
反应条件
1: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 2: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT 3: 76 percent / KMnO4, MgSO4 / acetone / 0.5 h / Ambient temperature 4: 94 percent / H2 / 10percent Pd/C / methanol / 6 h / 2327.2 Torr / Ambient temperature View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
1: With acylase I from Aspergillus species in toluene T=20°C; 6 h; Enzymatic reaction; 2: With phosphate buffer; acylase I from Aspergillus species in water T=20°C; pH=7.0; 7 h; Enzymatic reaction;
参考文献
Salgado, Antonio; Mann, Enrique; Sanchez-Sancho, Francisco; Herradon, Bernardo
Heterocycles, 2003 , vol. 60, # 1 p. 57 - 71
反应条件
acylase I from Aspergillus species in toluene T=20°C; 6 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Salgado, Antonio; Mann, Enrique; Sanchez-Sancho, Francisco; Herradon, Bernardo
Heterocycles, 2003 , vol. 60, # 1 p. 57 - 71
