1: 81 percent / pyridine / Ambient temperature 2: 99 percent / pyridine / CHCl3 / Ambient temperature 3: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 4: t-BuOK / tetrahydrofuran / Ambient temperature 5: dimethylformamide / 80 °C 6: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 7: 68.7 percent / pyridine / 72 h / Ambient temperature 8: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 9: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 10: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 11: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 81 percent / pyridine / Ambient temperature 2: 99 percent / pyridine / CHCl3 / Ambient temperature 3: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 4: t-BuOK / tetrahydrofuran / Ambient temperature 5: dimethylformamide / 80 °C 6: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 7: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 8: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: 78 percent / pyridine / CH2Cl2 / 50 °C 2: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: 81 percent / pyridine / Ambient temperature 2: 99 percent / pyridine / CHCl3 / Ambient temperature 3: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 4: t-BuOK / tetrahydrofuran / Ambient temperature 5: dimethylformamide / 80 °C 6: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 7: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme

1: 93.5 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH2Cl2; dimethylformamide / 24 h / Ambient temperature 2: 60 percent / 4-(N,N-dimethylamino)pyridine, DCC / CH2Cl2 / 96 h / Ambient temperature 3: 75 percent / pyridinium p-toluenesulfonate, MeOH / CH2Cl2 / 0 - 5 °C View Scheme