N-(2-二甲氨基乙基)-N-甲基甲酰胺合成路线 （共 5 条）
反应条件
in water 18 h; Ambient temperature;
参考文献
Dale, Johannes; Sigvartsen, Turid
Acta Chemica Scandinavica, 1991 , vol. 45, # 10 p. 1064 - 1070
参考文献
Tetrahedron Letters, , vol. 27, # 16 p. 1791 - 1792
反应条件
1: 2-methoxy-pyridine With methyllithium; diisopropylamine in tetrahydrofuran; diethyl ether T=-40 - 0°C; 2: N-(2-dimethylaminoethyl)-N-methylformamide in tetrahydrofuran; diethyl ether T=-78 - -40°C; 3: With n-butyllithium; iodine in tetrahydrofuran; diethyl ether; hexane T=-78 - 0°C; 4.5 h;
参考文献
Gabarda, Ana E; Du, Wu; Isarno, Thomas; Tangirala, Raghuram S; Curran, Dennis P
Tetrahedron, 2002 , vol. 58, # 32 p. 6329 - 6341
反应条件
1: 2-methoxy-pyridine With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 1 h; 2: N-(2-dimethylaminoethyl)-N-methylformamide in tetrahydrofuran; pentane T=-78 - -23°C; 1 h; 3: With n-butyllithium; iodine more than 3 stages;
参考文献
Marinier, Anne; Roy, Stephan; Martel, Alain
Patent: US2005/187218 A1, 2005 ;
Location in patent: Page/Page column 11 ;
US 20050187218 A1
反应条件
hydrogenchloride; n-butyllithium; iodine; tert.-butyl lithium; sodium thiosulfate in tetrahydrofuran; ethylene glycol dimethyl ether; hexane; water; pentane
参考文献
Glaxo Wellcome Inc.
Patent: US5491237 A1, 1996 ;
