6-溴-3,4-二氢-2H-1,4-苯并恶嗪合成路线 （共 13 条）
反应条件
1: With borane-THF in tetrahydrofuran T=20°C; 1.16667 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
WO2008/44022 A1, ;
Page/Page column 29 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 4 h;
参考文献
WO2011/130628 A1, ;
Page/Page column 227 ;
WO 2011/130628 A1
反应条件
potassium hydroxide in methanol T=55°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
potassium carbonate in dimethyl sulfoxide T=80°C;
参考文献
Heterocyclic Communications, , vol. 18, # 3 p. 143 - 146
反应条件
1: 74 percent / SnCl2*2H2O, concd. HCl / methanol / 16 h / Ambient temperature 2: pyridine / 0.08 h / Heating 3: 1 M methanolic NaOH / Ambient temperature 4: 90 percent / NaOH, Aliquat 336 / CH2Cl2; acetonitrile / 18 h / Ambient temperature 5: aq. KOH / methanol / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
1: pyridine / 0.08 h / Heating 2: 1 M methanolic NaOH / Ambient temperature 3: 90 percent / NaOH, Aliquat 336 / CH2Cl2; acetonitrile / 18 h / Ambient temperature 4: aq. KOH / methanol / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
1: 97 percent / HNO3-SiO2 / CH2Cl2 / 0.08 h / 0 °C 2: 74 percent / SnCl2*2H2O, concd. HCl / methanol / 16 h / Ambient temperature 3: pyridine / 0.08 h / Heating 4: 1 M methanolic NaOH / Ambient temperature 5: 90 percent / NaOH, Aliquat 336 / CH2Cl2; acetonitrile / 18 h / Ambient temperature 6: aq. KOH / methanol / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
1: 1 M methanolic NaOH / Ambient temperature 2: 90 percent / NaOH, Aliquat 336 / CH2Cl2; acetonitrile / 18 h / Ambient temperature 3: aq. KOH / methanol / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
1: 90 percent / NaOH, Aliquat 336 / CH2Cl2; acetonitrile / 18 h / Ambient temperature 2: aq. KOH / methanol / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1465 - 1474
反应条件
caesium carbonate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in acetonitrile T=85°C; 16 h; Inert atmosphere;
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
Location in patent: Page/Page column 293 ;
