1,2-双(3-氨丙基氨基)乙烷合成路线 （共 14 条）
反应条件
1: 91 percent / sodium hydroxide / H2O / 1.) 1 hr., 5 deg C, 2.) r.t., 3 hrs. 2: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating 3: 60 percent / sulfuric acid, (conc.) / 39 h / 100 °C View Scheme
参考文献
Luk'yanenko, N.G.; Basok, S.S.; Filonova, L.K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1731 - 1742
反应条件
1: 1.) NiCl2*6H2O, 2.) 2M aq. NaOH, Raney alloy, 3.) NaCN
2: 1.2 g / dimethylformamide / 2 h / 110 - 120 °C
View Scheme
参考文献
Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695
反应条件
1: 91 percent / sodium hydroxide / H2O / 1.) 1 hr., 5 deg C, 2.) r.t., 3 hrs.
2: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating
View Scheme
参考文献
Rubio, Mercedes; Astorga, Covadonga; Alfonso, Ignacio; Rebolledo, Francisca; Gotor, Vicente
Synthetic Communications, 2002 , vol. 32, # 16 p. 2441 - 2452
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane
70 h; Heating;
参考文献
Averin; Shukhaev; Buryak; Beletskaya
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 9 p. 1353 - 1364
