4-溴-3,5-二甲基异恶唑合成路线 （共 5 条）
反应条件
1: With N-bromosuccinmide in N,N-dimethyl-formamide T=75°C; 3 h; 2: With sodium hydrogencarbonate in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara
Patent: WO2012/11125 A1, 2012 ;
Location in patent: Page/Page column 148; 149 ;
WO 2012/011125 A1
反应条件
trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); cesium fluoride in 1,4-dioxane T=20 - 80°C; Stille-Migita cross-coupling; 24 h; Molecular sieveInert atmosphere;
参考文献
Dowlut, Meenakshi; Mallik, Debasis; Organ, Michael G.
Chemistry - A European Journal, 2010 , vol. 16, # 14 p. 4279 - 4283
反应条件
[(Pd(.mu.-Cl)(.kappa.(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; C25H23OP; potassium acetate in N,N-dimethyl acetamide T=100°C; Miyaura borylation; 12 h; Inert atmosphere;
参考文献
Tang, Wenjun; Keshipeddy, Santosh; Zhang, Yongda; Wei, Xudong; Savoie, Jolaine; Patel, Nitinchandra D.; Yee, Nathan K.; Senanayake, Chris H.
Organic Letters, 2011 , vol. 13, # 6 p. 1366 - 1369
反应条件
1: 4-bromo-3,5-dimethylisoxazole With diisobutylaluminium hydride; magnesium; lithium chloride; zinc(II) chloride in tetrahydrofuran T=23°C; Inert atmosphere; 2: trichloromethylcarbonyl isocyanate in tetrahydrofuran T=-20 - 25°C; Inert atmosphere; 3: With methanol; potassium carbonate in tetrahydrofuran T=25°C; 12 h; Inert atmosphere;
参考文献
Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul
Organic Letters, 2010 , vol. 12, # 16 p. 3648 - 3650
反应条件
1: 4-bromo-3,5-dimethylisoxazole With n-butyllithium in tetrahydrofuran T=-65°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 16 h; 3: With water; ammonium chloride T=20°C;
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara
Patent: WO2012/11125 A1, 2012 ;
Location in patent: Page/Page column 148-149 ;
WO 2012/011125 A1
