(2R, 3S)-(-)-对甲氧苯基缩水甘油酸甲酯合成路线 （共 38 条）
反应条件
sodium methylate in methanol T=0 - 20°C;
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1313 - 1315
反应条件
Oxonereg;; sodium hydrogencarbonate; chiral binaphthyl ketone C25H16O5 in 1,4-dioxane; water T=5 - 27°C; 27 h; Product distribution; Further Variations:CatalystsSolvents;
参考文献
Tetrahedron Letters, , vol. 42, # 46 p. 8201 - 8205
反应条件
triethylamine; 2-chloro-1-methylpyridinium sulfate in dichloromethane; 1,2-dichloro-ethane Ambient temperature;
参考文献
Yamamoto; Hayashi; Masaki; Nohira
Tetrahedron Asymmetry, 1991 , vol. 2, # 6 p. 403 - 406
反应条件
1: 3-(4-methoxy-phenyl)acrylic acid methyl ester With Oxonereg;; (R)-1,1'-binaphthyl-2,2'-dicarboxylic acid cyclic ester in 1,4-dioxane; water 26 h; 2: butan-1-ol With Serratia marcescens lipase on celit 25 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 67, # 13 p. 4599 - 4601
反应条件
sodium hypochlorite; 4-phenylpyridine-N-oxide; (salen)Mn(III)-complex in water; 1,2-dichloro-ethane T=4°C; 12 h; Yield given. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 50, # 15 p. 4323 - 4334
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=5 - 20°C; 0.583333 h;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 19 p. 3131 - 3138
反应条件
1: chiral oxaborolidine / CH2Cl2 / 7 h / -78 °C 2: Zn / acetic acid / 20 °C 3: NaOMe / methanol / 0 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1313 - 1315
反应条件
1: 85 percent / conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 2: 88 percent / Et3N / CH2Cl2 / Ambient temperature 3: 47 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature 4: 31 percent / CoCl2*6H2O / H2O / 6 h / 33 - 41 °C / aminoacylase, pH = 7.0 5: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature 6: diethyl ether / 0.17 h / Ambient temperature 7: 74 percent / K2CO3 / methanol; diethyl ether / 0.5 h / 0 - 5 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 9 p. 1521 - 1523
反应条件
1: 88 percent / aq. NaNO2, AcOH / 2 h 2: 85 percent / conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature 3: 88 percent / Et3N / CH2Cl2 / Ambient temperature 4: 47 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature 5: 31 percent / CoCl2*6H2O / H2O / 6 h / 33 - 41 °C / aminoacylase, pH = 7.0 6: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature 7: diethyl ether / 0.17 h / Ambient temperature 8: 74 percent / K2CO3 / methanol; diethyl ether / 0.5 h / 0 - 5 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 9 p. 1521 - 1523
反应条件
5A molecular sieve; Novozym 435 (Candida antarctica lipase, EC 3.1.1.3) in toluene T=20°C; Enzymatic reaction; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 6-7 p. 721 - 725
