2-溴-5-氟-3-硝基苯甲酸合成路线 （共 2 条）
反应条件
sulfuric acid; nitric acid T=5 - 10°C; 2.5 h; Inert atmosphere;
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
Location in patent: Page/Page column 46; 47 ;
反应条件
1: thionyl chloride / 1 h / 10 - 65 °C / |Inert atmosphere 2: acetic acid; iron / ethanol / 1 h / 85 °C / |Inert atmosphere 3: 5 palladium on charcoal; hydrogen / methanol; water / 6 h / |Inert atmosphere View Scheme
参考文献
BEIGENE, LTD.; ZHOU, Changyou; REN, Bo; WANG, Hexiang
Patent: WO2013/97226 A1, 2013 ;
